E.Ī major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region. M., Kallioniemi, O.-P., Bailey-Wilson, J. (2005) refined the HPCX locus to a 150-kb region on Xq27-q28 between markers D3S2390 and bG82i1.0.īaffoe-Bonnie, A. For both the full-structure pedigrees (up to 7 generations) and the smaller subpedigrees, the linkage evidence was much reduced.īy linkage disequilibrium and haplotype analysis of Finnish families with X-linked prostate cancer with no male-to-male transmission, Baffoe-Bonnie et al.
#Pcsx 1 full#
Theta lod is a linkage statistic that is analogous to a 2-point lod score but utilizes full multipoint haplotype information. In a dataset containing pedigrees having no more than 5 generations, a multipoint theta lod score of 2.74 (p = 0.0002) was observed, which was considered statistically significant after correction for multiple testing. (2005) performed linkage analysis on 143 Utah pedigrees for the HPCX prostate cancer susceptibility locus. A subset of 18 pedigrees without male-to-male transmission showed negative or low positive 2-point lod scores and negative multipoint lod scores across the entire region.įarnham et al. Using both parametric and nonparametric linkage methods, no significant evidence of linkage was observed. (2001) examined evidence for linkage to the HPCX locus in 64 (37 previously reported and 27 newly identified) families from southern and western Europe with at least 3 affected individuals with prostate cancer and an average age at diagnosis of 66.4 years. Although this analysis did not show statistically significant evidence for the linkage of prostate cancer susceptibility to Xq27-q28, the results were considered consistent with a small percentage of families being linked to this region.Ĭancel-Tassin et al. In 81 families with no evidence of male-to-male transmission, they found a lod score of 1.062 at theta = 0.28 with DXS984. (2001) reported on linkage analysis at the putative HPCX locus in an independent set of 186 prostate cancer families. AR, however, is located at Xq12, over 50 cM from the region implicated in the study of Xu et al. A candidate prostate cancer susceptibility gene on the X chromosome is the androgen receptor gene (AR 313700).
The estimation of the proportion of X-linked families appeared to be the same in each family collection. Parametric multipoint and nonparametric analyses provided results consistent with the 2-point analysis. A maximum 2-point lod score of 4.60 was observed with DXS1113 at theta = 0.26 in the combined data set. Linkage to Xq27-q28 was observed in a combined study population of 360 prostate cancer families collected at 4 independent sites in North America, Finland, and Sweden. The finding was consistent with the results of a previous population-based study suggesting an X-linked mode of inheritance of prostate cancer. Heterogeneity estimates suggested that the gene accounts for approximately 16% of hereditary prostate cancer cases. (1998) presented evidence for the location of a prostate cancer susceptibility gene, which they symbolized HPCX, on Xq27-q28.
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